Clinical Panels and Targeted Sequencing
AGRF is your trusted partner in world class clinical genomics with NATA accreditation for oncology and screening assays.
TruSight® Oncology 500
The TSO500 panel is used to identify genetic mutations and alterations in patient tumour DNA/RNA, providing valuable insights into a variety of cancers. The panel includes multiple variant types and key biomarkers across 523 cancer-relevant genes in DNA and 55 genes in RNA. This information can play a role in selecting appropriate cancer treatments, understanding prognosis, and conducting research on cancer genetics. Our Next Generation Sequencing process from sample to results, is completed in under 14 days*, providing high quality secondary analysis demonstrating concordance in detecting MSI, TMB, CNV, small variants and fusions.
Panel Size: 1.94 Mb DNA, 358 kb RNA
For more information, take a look at our TSO500 service guide.
*Samples submitted as DNA/RNA and successfully pass quality control (QC) and do not require extraction.
Twist Exome 2.0
Discover the power of the Twist Exome 2.0 panel (36.5 Mbp) designed for detecting rare disease, inherited conditions as well as germline cancers. Delivering high-quality data with superior coverage based on major genetic databases (RefSeq, CCDS, GenCode, ClinVar, ACMG73), addressing inherited diseases including cystic fibrosis (CFTR) and targeting other clinically relevant markers.1 Additionally, you have the option to include the mtDNA genome as a spike-in probe set upon request, or you can introduce your Twist compatible probe spike-in for a customised service. Additional charges may apply.
Twist Alliance Clinical Research Exome
Our comprehensive NGS service includes the Broad Institute designed Twist Alliance Clinical Research Exome panel (34.9 Mbp). This panel covers an extensive range of clinically relevant areas of the genome linked to cancers, rare diseases and inherited conditions. This panel is built on the Twist Core Exome backbone, providing enhanced coverage with the inclusion of the mtDNA genome at no extra cost, along with boosted coverage for Online Mendelian Inheritance in Man (OMIM), Catalogue of Somatic Mutations in Cancer (COSMIC) and non-exonic regions such as ACMG73.2
Contact our experienced clinical team for more information today.
Your trusted partners. Excellence in quality and expertise.
Dr Mathi Appavoo
Clinical Genomics Specialist
M: +61 456 435 712
E: Mathi.Appavoo@agrf.org.au
References
Twist BioScience Exome 2.0
Twist Bioscience Alliance Panels
