Variant Discovery

Variant discovery has applications in a number of areas.  For research in model organisms, variant discovery projects are typically interested in finding rare mutations in genes responsible for Mendelian diseases or cancer.  For research into non-model organisms variant discovery projects are focused on finding SNPs or microsatellites that could be used as breeding/population markers.  Once discovered these markers can be genotyped rapidly and affordably using other approaches.  We offer methods to reduce genome complexity (i.e. RADSeq) allowing affordable discovery projects on large genomes.

The service is carried out using our Next Generation sequencing Illumina HiSeq and MiSeq platforms.

Details on how to use out Next Generation sequencing service can be found here

News

Aboriginal mitogenome analysis shows 50,000 years of connection to country

16 March 2017

Genomic analysis of hair samples collected from Australian Aboriginals across the nation have indicated that cultural connection to country has existed for as many as 50,000 years. 

The Aboriginal Heritage Project, led by the University of Adelaide’s Australian Centre for Ancient DNA recently published their findings in the journal Nature (online 8th March 2017).  AGRF is proud to be associated with the work as part of an ARC linkage grant, with the AGRF’s Operations Manager Dr John Stephen as a Partner Investigator.

Read more ›